SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

Toshio Kanno; Takahiro Nakajima; Satoru Yokoyama; Hikari K. Asou; Shigemi Sasamoto; Yasuhiro Kamii; Koji Hayashizaki; Yasuo Ouchi; Taishi Onodera; Yoshimasa Takahashi; Kazutaka Ikeda; Yoshinori Hasegawa; Yuki Kinjo; Osamu Ohara; Toshinori Nakayama; Yusuke Endo

doi:10.1038/s42003-021-02310-y

Communications Biology (Jun 2021)

SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

Toshio Kanno,
Takahiro Nakajima,
Satoru Yokoyama,
Hikari K. Asou,
Shigemi Sasamoto,
Yasuhiro Kamii,
Koji Hayashizaki,
Yasuo Ouchi,
Taishi Onodera,
Yoshimasa Takahashi,
Kazutaka Ikeda,
Yoshinori Hasegawa,
Yuki Kinjo,
Osamu Ohara,
Toshinori Nakayama,
Yusuke Endo

Affiliations

Toshio Kanno: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute
Takahiro Nakajima: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute
Satoru Yokoyama: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute
Hikari K. Asou: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute
Shigemi Sasamoto: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute
Yasuhiro Kamii: Department of Bacteriology, The Jikei University School of Medicine
Koji Hayashizaki: Department of Bacteriology, The Jikei University School of Medicine
Yasuo Ouchi: Gene Expression Laboratory (GEL-B) Salk Institute for Biological Studies
Taishi Onodera: Department of Immunology, National Institute of Infectious Disease
Yoshimasa Takahashi: Department of Immunology, National Institute of Infectious Disease
Kazutaka Ikeda: Department of Applied Genomics Kazusa DNA Research Institute
Yoshinori Hasegawa: Department of Applied Genomics Kazusa DNA Research Institute
Yuki Kinjo: Department of Bacteriology, The Jikei University School of Medicine
Osamu Ohara: Department of Applied Genomics Kazusa DNA Research Institute
Toshinori Nakayama: Department of Immunology, Graduate School of Medicine, Chiba University
Yusuke Endo: Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute

DOI: https://doi.org/10.1038/s42003-021-02310-y
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired immune response.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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