Frontiers in Neurology (Oct 2023)

Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia

  • Caio César Diniz Disserol,
  • Caio César Diniz Disserol,
  • Dora Pedroso Kowacs,
  • Samir Kanaan Nabhan,
  • Hélio Afonso Ghizoni Teive,
  • Pedro André Kowacs,
  • Pedro André Kowacs

DOI
https://doi.org/10.3389/fneur.2023.1254981
Journal volume & issue
Vol. 14

Abstract

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The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease.

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