Nature Communications (Mar 2021)
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
- Sara De Biasi,
- Lara Gibellini,
- Domenico Lo Tartaro,
- Simone Puccio,
- Claudio Rabacchi,
- Emilia M. C. Mazza,
- Jolanda Brummelman,
- Brandon Williams,
- Kelly Kaihara,
- Mattia Forcato,
- Silvio Bicciato,
- Marcello Pinti,
- Roberta Depenni,
- Roberto Sabbatini,
- Caterina Longo,
- Massimo Dominici,
- Giovanni Pellacani,
- Enrico Lugli,
- Andrea Cossarizza
Affiliations
- Sara De Biasi
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Lara Gibellini
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Domenico Lo Tartaro
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Simone Puccio
- Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital
- Claudio Rabacchi
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Emilia M. C. Mazza
- Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital
- Jolanda Brummelman
- Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital
- Brandon Williams
- Bio-Rad Laboratories
- Kelly Kaihara
- Bio-Rad Laboratories
- Mattia Forcato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Silvio Bicciato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Marcello Pinti
- Department of Life Sciences, University of Modena and Reggio Emilia
- Roberta Depenni
- Department of Oncology, University of Modena & Reggio Emilia
- Roberto Sabbatini
- Department of Oncology, University of Modena & Reggio Emilia
- Caterina Longo
- Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia
- Massimo Dominici
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Giovanni Pellacani
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- Enrico Lugli
- Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital
- Andrea Cossarizza
- Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia
- DOI
- https://doi.org/10.1038/s41467-021-21928-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages show different response rates, and ICI responders have more MAIT cells expressing CXCR4 and granzyme B.
