Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives

Abstract

Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a] pyrimidine-6-carboxylate (4a–g) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (1), various aromatic benzaldehyde (2a–g) and ethylacetoacetate (3). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT–IR spectral features. Compounds 4a–g were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacterial strains (Salmonella typhimurium and Escherichia coli). Compounds 4a–g were also examined for antifungal activity against different fungal strains, i.e. Penicillium expansum, Botryodiplodia theobromae, Nigrospora sp., and Trichothesium sp. DOI: http://dx.doi.org/10.17807/orbital.v9i4.879

Keywords

• antimicrobial activity
• solvent-free
• one-pot synthesis
• thiazolo[3,2-a]pyrimidine