Journal of the Scientific Society (Jan 2023)

An inclusive exploration of forced degradation analysis of some therapeutic categories of drugs in the last decade

  • Jasdev Singh Tuteja,
  • Anamika Singh,
  • Tamanna Narsinghani

DOI
https://doi.org/10.4103/jss.jss_244_22
Journal volume & issue
Vol. 50, no. 3
pp. 312 – 344

Abstract

Read online

In the pharmaceutical industry, forced degradation tests are used to assess the stability of drug samples. Examining degradation products under stress is beneficial for determining degradation pathways as well as designing and validating appropriate analytical techniques. Forced degradation experiments reveal the molecule's chemical behavior, which aids formulation and packaging creation. The current review examines the forced degradation of a variety of therapeutic classes of medications, including anticancer, antihypertensive, antiviral, CNS pharmaceuticals, and other miscellaneous drugs. During forced degradation analysis, the study examines the degradation behavior of several medications from the abovementioned categories. The findings will likely aid researchers in determining the degradation process of related drugs belonging to the same category.

Keywords