mSystems
(Oct 2021)
Higher Trimethylamine-
<i>N</i>
-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
Silke Rath,
Katharina Rox,
Sven Kleine Bardenhorst,
Ulf Schminke,
Marcus Dörr,
Julia Mayerle,
Fabian Frost,
Markus M. Lerch,
André Karch,
Mark Brönstrup,
Dietmar H. Pieper,
Marius Vital
Affiliations
Silke Rath
Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
Katharina Rox
Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Sven Kleine Bardenhorst
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
Ulf Schminke
Department of Neurology, University Medicine Greifswald, Greifswald, Germany
Marcus Dörr
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
Julia Mayerle
Department of Medicine II, University Hospital Munich, Ludwig-Maximillian University Munich, Munich, Germany
Fabian Frost
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
Markus M. Lerch
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
André Karch
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
Mark Brönstrup
ORCiD Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Dietmar H. Pieper
Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
Marius Vital
ORCiD Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
DOI
https://doi.org/10.1128/mSystems.00945-21
Journal volume & issue
Vol. 6,
no. 5
Abstract
Read online
Many cohort studies have investigated the link between diet and plasma TMAO levels, reporting incongruent results, while gut microbiota were only recently included into analyses. In these studies, taxonomic data were recorded that are not a good proxy for TMA formation, as specific members of various taxa exhibit genes catalyzing this reaction, demanding function-based technologies for accurate quantification of TMA-synthesizing bacteria.
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