Research progress on vascular calcification mechanism for chronic kidney disease

Abstract

Cardiovascular events are the main cause of death in chronic kidney disease(CKD) and end stage renal disease(ESRD).Studies have shown that vascular calcification is an independent risk factor for cardiovascular events.In addition to the prevention of cardiovascular events,paying attention to the mechanism of vascular calcification, keeping balance of pro-calcification factors and anti-calcification factors should be the primary concerns in prevention and treatment of chronic kidney disease with CKD-mineral and bone disorder(CKD-MBD) in CKD patients.

Keywords

• chronic kidney disease|vascular calcification|calcium and phosphate metabolism|fgf23/klotho|inflammatory injury