Sodium valproate-induced necrotizing pancreatitis in a patient with bipolar mania

Abstract

Bipolar disorder is a chronic complex disorder that requires lifelong maintenance treatment. Sodium valproate is an effective first-line drug for bipolar mania. Adverse effects associated with valproate are typically benign, but there are serious adverse effects that are less frequently seen. Acute pancreatitis is a very rare side effect seen with valproate use with a high mortality rate. We report the case of a 24-year-old male patient with bipolar mania who developed acute necrotizing pancreatitis with sodium valproate.

Keywords

• bipolar mania
• drug-induced
• mood stabilizer
• necrotizing pancreatitis
• sodium valproate