Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Abstract

Background: Mastitis is an inflammatory response in the mammary gland that results in huge economic losses in the breeding industry. The aetiology of mastitis is complex, and the pathogenesis has not been fully elucidated. It is commonly believed that mastitis is induced by pathogen infection of the mammary gland and induces a local inflammatory response. However, in the clinic, mastitis is often comorbid or secondary to gastric disease, and local control effects targeting the mammary gland are limited. In addition, recent studies have found that the gut/rumen microbiota contributes to the development of mastitis and proposed the gut/rumen–mammary gland axis. Combined with studies indicating that gut/rumen microbiota disturbance can damage the gut mucosa barrier, gut/rumen bacteria and their metabolites can migrate to distal extraintestinal organs. It is believed that the occurrence of mastitis is related not only to the infection of the mammary gland by external pathogenic microorganisms but also to a gastroenterogennic pathogenic pathway. Aim of review: We propose the pathological concept of “gastroenterogennic mastitis” and believe that the gut/rumen–mammary gland axis–mediated pathway is the pathological mechanism of “gastroenterogennic mastitis”. Key scientific concepts of review: To clarify the concept of “gastroenterogennic mastitis” by summarizing reports on the effect of the gut/rumen microbiota on mastitis and the gut/rumen–mammary gland axis–mediated pathway to provide a research basis and direction for further understanding and solving the pathogenesis and difficulties encountered in the prevention of mastitis.

Keywords

• Dairy cows
• Gastroenterogennic mastitis
• Gut/rumen-mammary gland axis
• Microbiota