Plastic and Reconstructive Surgery, Global Open (Apr 2022)

BRCA2-associated Breast Cancer in Transgender Women: Reconstructive Challenges and Literature Review

  • Naomi A. Cole, BS,
  • Libby R. Copeland-Halperin, MD,
  • Nina Shank, MD,
  • Vidya Shankaran, MD

DOI
https://doi.org/10.1097/GOX.0000000000004059
Journal volume & issue
Vol. 10, no. 4
p. e4059

Abstract

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Summary:. Breast cancer in trans women is rare. Only 21 cases have been reported worldwide. Multidisciplinary teams must balance oncologic treatment with patient goals. Here we describe a case of invasive ductal carcinoma in a transgender woman who was found to have a BRCA2 gene mutation. A shared decision-making process led to the patient undergoing bilateral nipple-sparing mastectomy with immediate tissue expander placement. Later findings prompted discussions about adjuvant chemotherapy and radiation. Additionally, we discuss the complexities associated with reconstructing a transfeminine chest.