Topical Methotrexate In Localized Psoriasis

Abstract

A comparative study of topical methotrexate and topical tar in eighteen patients of localized psoriasis with bilateral involvement of both lower legs, equal in area and disease severity was carried out. The patients were asked to apply topical methorexate 0.25% in a hydrophilic gel twice daily on right leg. The test sites were score, before therapy, after one month and after two months. The result with topical methotrexate preparation was promising but was comparable to topical tar formulation.