Pharmaceutics (Mar 2023)

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

  • Ylenia Della Rocca,
  • Enrico Matteo Traini,
  • Francesca Diomede,
  • Luigia Fonticoli,
  • Oriana Trubiani,
  • Alessia Paganelli,
  • Jacopo Pizzicannella,
  • Guya Diletta Marconi

DOI
https://doi.org/10.3390/pharmaceutics15030908
Journal volume & issue
Vol. 15, no. 3
p. 908

Abstract

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Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.

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