Case Reports in Urology (Jan 2013)

Long-Term Survival of a Patient with Invasive Signet-Ring Cell Carcinoma of the Urinary Bladder Managed by Combined S-1 and Cisplatin Adjuvant Chemotherapy

  • Takashi Hamakawa,
  • Yoshiyuki Kojima,
  • Taku Naiki,
  • Yasue Kubota,
  • Takahiro Yasui,
  • Keiichi Tozawa,
  • Yutaro Hayashi,
  • Kenjiro Kohri

DOI
https://doi.org/10.1155/2013/915874
Journal volume & issue
Vol. 2013

Abstract

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Primary signet-ring cell carcinoma of the urinary bladder is extremely rare and patient survival is very poor. The disease usually presents at advanced stages because the cancer progresses rapidly. The only option for effective treatment is radical cystectomy, and no effective chemotherapy has been established for this variant. We report a case of signet-ring cell carcinoma of the urinary bladder with a long-term survival of 90 months owing to radical cystectomy and combination adjuvant chemotherapy with S-1 and cisplatin. To our knowledge, this is the first report to demonstrate the long-term therapeutic activity of combination S-1 and cisplatin adjuvant chemotherapy against invasive signet-ring cell carcinoma of the urinary bladder.