Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation

Decha Pinkaew; Erik Martinez-Hackert; Wei Jia; Matthew D. King; Fei Miao; Nicole R. Enger; Runglawan Silakit; Kota Ramana; Shi-You Chen; Ken Fujise

doi:10.1038/s42003-022-03112-6

Communications Biology (Feb 2022)

Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation

Decha Pinkaew,
Erik Martinez-Hackert,
Wei Jia,
Matthew D. King,
Fei Miao,
Nicole R. Enger,
Runglawan Silakit,
Kota Ramana,
Shi-You Chen,
Ken Fujise

Affiliations

Decha Pinkaew: Division of Cardiology, Department of Medicine, University of Washington
Erik Martinez-Hackert: Department of Biochemistry and Molecular Biology, Michigan State University
Wei Jia: Department of Surgery, University of Missouri
Matthew D. King: Department of Chemistry and Biochemistry, Boise State University
Fei Miao: Division of Cardiology, Department of Medicine, University of Washington
Nicole R. Enger: Division of Cardiology, Department of Medicine, University of Washington
Runglawan Silakit: Division of Cardiology, Department of Medicine, University of Washington
Kota Ramana: Department of Biochemistry, Noorda College of Osteopathic Medicine
Shi-You Chen: Department of Surgery, University of Missouri
Ken Fujise: Division of Cardiology, Department of Medicine, University of Washington

DOI: https://doi.org/10.1038/s42003-022-03112-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Fortilin prevents the activation of the TGF-β1 receptor by occupying the pocket of TGF-β1 and competing with TGF-βRII to bind with TGF-β1. This inhibits Smad3 phosphorylation and the differentiation of C3H10T1/2 mesenchymal progenitor cells to smooth muscle cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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