Nature Communications (Aug 2021)
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
- Aartik Sarma,
- Stephanie A. Christenson,
- Ashley Byrne,
- Eran Mick,
- Angela Oliveira Pisco,
- Catherine DeVoe,
- Thomas Deiss,
- Rajani Ghale,
- Beth Shoshana Zha,
- Alexandra Tsitsiklis,
- Alejandra Jauregui,
- Farzad Moazed,
- Angela M. Detweiler,
- Natasha Spottiswoode,
- Pratik Sinha,
- Norma Neff,
- Michelle Tan,
- Paula Hayakawa Serpa,
- Andrew Willmore,
- K. Mark Ansel,
- Jennifer G. Wilson,
- Aleksandra Leligdowicz,
- Emily R. Siegel,
- Marina Sirota,
- Joseph L. DeRisi,
- Michael A. Matthay,
- COMET Consortium,
- Carolyn M. Hendrickson,
- Kirsten N. Kangelaris,
- Matthew F. Krummel,
- Prescott G. Woodruff,
- David J. Erle,
- Carolyn S. Calfee,
- Charles R. Langelier
Affiliations
- Aartik Sarma
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Stephanie A. Christenson
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Ashley Byrne
- Chan Zuckerberg Biohub
- Eran Mick
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Angela Oliveira Pisco
- Chan Zuckerberg Biohub
- Catherine DeVoe
- Division of Infectious Diseases, University of California
- Thomas Deiss
- Chan Zuckerberg Biohub
- Rajani Ghale
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Beth Shoshana Zha
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Alexandra Tsitsiklis
- Division of Infectious Diseases, University of California
- Alejandra Jauregui
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Farzad Moazed
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Angela M. Detweiler
- Division of Infectious Diseases, University of California
- Natasha Spottiswoode
- Department of Medicine, University of California
- Pratik Sinha
- Department of Anesthesia, Washington University
- Norma Neff
- Chan Zuckerberg Biohub
- Michelle Tan
- Chan Zuckerberg Biohub
- Paula Hayakawa Serpa
- Division of Infectious Diseases, University of California
- Andrew Willmore
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- K. Mark Ansel
- Department of Microbiology and Immunology, University of California
- Jennifer G. Wilson
- Department of Emergency Medicine, Stanford University
- Aleksandra Leligdowicz
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Emily R. Siegel
- School of Medicine, University of California
- Marina Sirota
- Division of Rheumatology, University of California
- Joseph L. DeRisi
- Chan Zuckerberg Biohub
- Michael A. Matthay
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- COMET Consortium
- Carolyn M. Hendrickson
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Kirsten N. Kangelaris
- Department of Medicine, University of California
- Matthew F. Krummel
- Department of Pathology, University of California
- Prescott G. Woodruff
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- David J. Erle
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Carolyn S. Calfee
- Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California
- Charles R. Langelier
- Chan Zuckerberg Biohub
- DOI
- https://doi.org/10.1038/s41467-021-25040-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.
