Studying the Causes of Virologic Failure in the Early Stages of Antiretroviral Therapy in HIV-Infected Patients

Abstract

556 HIV-infected patients who received antiretroviral therapy (ART) for 6 months were examined for the level of HIV viral load. In 5.92 % of cases we diagnosed viral load above 1,000 RNA copies/ml that indicated virologic failure of ART. On the basis of molecular genetic analysis of the HIV genome, it was found that among the factors influencing the formation of virologic failure of ART in the early stages, one of the most important is noncompliance of antiretroviral drug therapy in patients (low adherence to therapy).

Keywords

• HIV
• level of HIV viral load
• antiretroviral therapy
• virologic efficiency of antiretroviral therapy
• mutation of HIV resistance