DNA甲基化与高同型半胱氨酸血症 DNA Methylation and Hyperhomocysteinemia

Abstract

DNA甲基化是一种调控基因表达的表观遗传机制，由Hcy代谢相关底物S-腺苷同型半胱氨酸（S-adenosyl-L-homocysteine，SAH）依赖性的DNA甲基转移酶（DNA methyltransferases，DNMTs）催化，对维持细胞稳态至关重要。多项研究表明，高同型半胱氨酸血症（hyperhomocysteinemia，HHcy）可能通过调节甲硫氨酸-同型半胱氨酸循环（methionine-homocysteine cycle，M-H cycle）调控DNA甲基化状态，参与动脉粥样硬化形成过程中的血管内皮细胞功能障碍、损伤后平滑肌细胞（smooth muscle cells，SMCs）的增殖和转移、脂质代谢等病理过程，从而影响心血管疾病的发生和预后。 DNA methylation is a process catalyzed by DNA methyltransferases (DNMTs) , which is dependent on S-adenosyl-L-homocysteine (SAH) , a substrate related to the metabolism of Hcy. It is an epigenetic mechanism that regulates gene expression, and is critical for maintaining cellular homeostasis. A number of studies have shown that hyperhomocysteinemia (HHcy) may regulate DNA methylation status by regulating the methionine-homocysteine cycle (M-H cycle) , which is involved in multiple pathological process of atherosclerosis formation such as dysfunction of endothelial cells, proliferation and metastasis of damaged smooth muscle cells (SMCs) , and lipid metabolism, then can influence the occurrence and prognosis of cardiovascular diseases.

Keywords

• 脱氧核糖核酸
• 甲基化
• 高同型半胱氨酸血症
• 卒中
• 动脉粥样硬化
• 心血管疾病
• dna
• methylation
• hyperhomocysteinemia
• stroke
• atherosclerosis
• cardiovascular disease