Association between Dental Scores and Saliva Uremic Toxins
Claire Rigothier,
Sylvain Catros,
Antoine Bénard,
Johan Samot,
Olivier Quintin,
Christian Combe,
Islam Larabi,
Ziad Massy,
Jean-Claude Alvarez
Affiliations
Claire Rigothier
Service de Néphrologie-Transplantation-Dialyse-Aphérèses, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France
Sylvain Catros
INSERM, Bio-Ingénierie Tissulaire (BioTis), UMR 1026, Université de Bordeaux, 33076 Bordeaux, France
Antoine Bénard
Clinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France
Johan Samot
Département de Chirurgie Orale, CHU de Bordeaux, 33076 Bordeaux, France
Olivier Quintin
Clinical Epidemiology Unit (USMR), CHU de Bordeaux, 33076 Bordeaux, France
Christian Combe
Service de Néphrologie-Transplantation-Dialyse-Aphérèses, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France
Islam Larabi
Service de Pharmacologie-Toxicologie, Hôpital Raymond Poincaré, AP-HP, 92380 Garchesy, France
Ziad Massy
Centre for Research in Epidemiology and Population Health, Inserm UMRS 1018, Clinical Epidemiology Team, Université Paris Saclay (Versailles Saint Quentin-en-Yvelines), 78035 Villejuif, France
Jean-Claude Alvarez
Service de Pharmacologie-Toxicologie, Hôpital Raymond Poincaré, AP-HP, 92380 Garchesy, France
Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.
