Impact of myocardial reperfusion on human plasma lipidome

Arun Surendran; Negar Atefi; Umar Ismail; Ashish Shah; Amir Ravandi

iScience (Feb 2022)

Impact of myocardial reperfusion on human plasma lipidome

Arun Surendran,
Negar Atefi,
Umar Ismail,
Ashish Shah,
Amir Ravandi

Affiliations

Arun Surendran: Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada; Mass Spectrometry and Proteomics Core Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014 Kerala, India; Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada
Negar Atefi: Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
Umar Ismail: Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada
Ashish Shah: Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada; Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada
Amir Ravandi: Cardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada; Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada; Section of Cardiology, Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada; Corresponding author

Journal volume & issue: Vol. 25, no. 2
p. 103828

Abstract

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Summary: The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly altered (corrected p< 0.05) in the first 24 h following reperfusion in patients with STEMI. Three lipid species, namely, acylcarnitine 18:2, TG 51:0, and LPC 17:1 were associated with a change in troponin concentration (delta troponin) and in-hospital cardiovascular events. Of these, acylcarnitine 18:2, and LPC 17:1 and their respective whole class levels, were significantly higher (p < 0.05) in the STEMI population than the age/sex-matched control subjects. Overall, our analyses showed a large shift in plasma lipidome in patients that undergo myocardial reperfusion. The differences found for acylcarnitines and LPC species and their association with both cardiac markers and cardiac outcomes need further validation.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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