Nature Communications (Aug 2016)
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
- Arvindhan Nagarajan,
- Max C. Petersen,
- Ali R. Nasiri,
- Gina Butrico,
- Annie Fung,
- Hai-Bin Ruan,
- Romy Kursawe,
- Sonia Caprio,
- Jacques Thibodeau,
- Marie-Claude Bourgeois-Daigneault,
- Lisha Sun,
- Guangping Gao,
- Sanjay Bhanot,
- Michael J. Jurczak,
- Michael R. Green,
- Gerald I. Shulman,
- Narendra Wajapeyee
Affiliations
- Arvindhan Nagarajan
- Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
- Max C. Petersen
- Howard Hughes Medical Institute, Yale University School of Medicine
- Ali R. Nasiri
- Department of Internal Medicine, Yale University School of Medicine
- Gina Butrico
- Department of Internal Medicine, Yale University School of Medicine
- Annie Fung
- Department of Internal Medicine, Yale University School of Medicine
- Hai-Bin Ruan
- Departments of Comparative Medicine, Yale University School of Medicine
- Romy Kursawe
- Departments of Pediatrics, Yale University School of Medicine
- Sonia Caprio
- Departments of Pediatrics, Yale University School of Medicine
- Jacques Thibodeau
- Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal
- Marie-Claude Bourgeois-Daigneault
- Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal
- Lisha Sun
- Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
- Guangping Gao
- Gene Therapy Center, University of Massachusetts Medical School
- Sanjay Bhanot
- Isis Pharmaceuticals
- Michael J. Jurczak
- Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh
- Michael R. Green
- Howard Hughes Medical Institute and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
- Gerald I. Shulman
- Howard Hughes Medical Institute, Yale University School of Medicine
- Narendra Wajapeyee
- Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
- DOI
- https://doi.org/10.1038/ncomms12639
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and, therefore, insulin signalling.
