Nature Communications (Jan 2023)
Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
- Alexandra M. Cheney,
- Stephanann M. Costello,
- Nicholas V. Pinkham,
- Annie Waldum,
- Susan C. Broadaway,
- Maria Cotrina-Vidal,
- Marc Mergy,
- Brian Tripet,
- Douglas J. Kominsky,
- Heather M. Grifka-Walk,
- Horacio Kaufmann,
- Lucy Norcliffe-Kaufmann,
- Jesse T. Peach,
- Brian Bothner,
- Frances Lefcort,
- Valérie Copié,
- Seth T. Walk
Affiliations
- Alexandra M. Cheney
- Department of Chemistry and Biochemistry, Montana State University
- Stephanann M. Costello
- Department of Chemistry and Biochemistry, Montana State University
- Nicholas V. Pinkham
- Department of Microbiology and Cell Biology, Montana State University
- Annie Waldum
- Department of Chemistry and Biochemistry, Montana State University
- Susan C. Broadaway
- Department of Microbiology and Cell Biology, Montana State University
- Maria Cotrina-Vidal
- Department of Neurology, New York University School of Medicine
- Marc Mergy
- Department of Microbiology and Cell Biology, Montana State University
- Brian Tripet
- Department of Chemistry and Biochemistry, Montana State University
- Douglas J. Kominsky
- Department of Microbiology and Cell Biology, Montana State University
- Heather M. Grifka-Walk
- Department of Microbiology and Cell Biology, Montana State University
- Horacio Kaufmann
- Department of Neurology, New York University School of Medicine
- Lucy Norcliffe-Kaufmann
- Department of Neurology, New York University School of Medicine
- Jesse T. Peach
- Department of Chemistry and Biochemistry, Montana State University
- Brian Bothner
- Department of Chemistry and Biochemistry, Montana State University
- Frances Lefcort
- Department of Microbiology and Cell Biology, Montana State University
- Valérie Copié
- Department of Chemistry and Biochemistry, Montana State University
- Seth T. Walk
- Department of Microbiology and Cell Biology, Montana State University
- DOI
- https://doi.org/10.1038/s41467-023-35787-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Familial dysautonomia is a rare genetic disease caused in part by neurodegeneration. Here, the authors show that the gut-metabolism axis is altered in both patients and transgenic mice and that disease pathology is ameliorated by controlling microbiome divergence.
