Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

Eline E. van Haaften; Sjeng Quicken; Wouter Huberts; Carlijn V. C. Bouten; Nicholas A. Kurniawan

doi:10.1038/s42003-021-02065-6

Communications Biology (May 2021)

Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

Eline E. van Haaften,
Sjeng Quicken,
Wouter Huberts,
Carlijn V. C. Bouten,
Nicholas A. Kurniawan

Affiliations

Eline E. van Haaften: Department of Biomedical Engineering, Eindhoven University of Technology
Sjeng Quicken: Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University
Wouter Huberts: Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University
Carlijn V. C. Bouten: Department of Biomedical Engineering, Eindhoven University of Technology
Nicholas A. Kurniawan: Department of Biomedical Engineering, Eindhoven University of Technology

DOI: https://doi.org/10.1038/s42003-021-02065-6
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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van Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in blood vessels and grafts.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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