Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling

Eun-Young Lee; Su-Man Kim; Jung Hwan Hwang; Song Yee Jang; Shinhye Park; Sanghyeon Choi; Ga Seul Lee; Jungwon Hwang; Jeong Hee Moon; Paul L. Fox; Sunghoon Kim; Chul-Ho Lee; Myung Hee Kim

doi:10.1038/s41467-022-34226-4

Nature Communications (Oct 2022)

Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling

Eun-Young Lee,
Su-Man Kim,
Jung Hwan Hwang,
Song Yee Jang,
Shinhye Park,
Sanghyeon Choi,
Ga Seul Lee,
Jungwon Hwang,
Jeong Hee Moon,
Paul L. Fox,
Sunghoon Kim,
Chul-Ho Lee,
Myung Hee Kim

Affiliations

Eun-Young Lee: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Su-Man Kim: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Jung Hwan Hwang: Laboratory Animal Resource Center, KRIBB
Song Yee Jang: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Shinhye Park: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Sanghyeon Choi: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Ga Seul Lee: Core Research Facility & Analysis Center, KRIBB
Jungwon Hwang: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Jeong Hee Moon: Core Research Facility & Analysis Center, KRIBB
Paul L. Fox: Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation
Sunghoon Kim: Medicinal Bioconvergence Research Center, College of Pharmacy and College of Medicine, Gangnam Severance Hospital, Yonsei University
Chul-Ho Lee: Laboratory Animal Resource Center, KRIBB
Myung Hee Kim: Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

DOI: https://doi.org/10.1038/s41467-022-34226-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The PI3K/AKT signaling pathway is carefully regulated in specific cellular compartments. Lee and colleagues show that the housekeeping gene glutamyl-prolyl-tRNA synthetase 1 coordinates early endosome-specific AKT signaling necessary for inflammation resolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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