Nature Communications (Jun 2019)
Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
- Wenguang Shao,
- Tiannan Guo,
- Nora C. Toussaint,
- Peng Xue,
- Ulrich Wagner,
- Li Li,
- Konstantina Charmpi,
- Yi Zhu,
- Jianmin Wu,
- Marija Buljan,
- Rui Sun,
- Dorothea Rutishauser,
- Thomas Hermanns,
- Christian Daniel Fankhauser,
- Cedric Poyet,
- Jelena Ljubicic,
- Niels Rupp,
- Jan H. Rüschoff,
- Qing Zhong,
- Andreas Beyer,
- Jiafu Ji,
- Ben C. Collins,
- Yansheng Liu,
- Gunnar Rätsch,
- Peter J. Wild,
- Ruedi Aebersold
Affiliations
- Wenguang Shao
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Tiannan Guo
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Nora C. Toussaint
- NEXUS Personalized Health Technologies, ETH Zurich
- Peng Xue
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Ulrich Wagner
- Institute of Surgical Pathology, University Hospital Zurich
- Li Li
- CECAD, University of Cologne
- Konstantina Charmpi
- CECAD, University of Cologne
- Yi Zhu
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Jianmin Wu
- Key laboratory of Carcinogenesis and Translational Research, Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute
- Marija Buljan
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Rui Sun
- School of Life Sciences, Westlake University
- Dorothea Rutishauser
- Institute of Surgical Pathology, University Hospital Zurich
- Thomas Hermanns
- Department of Urology, University of Zurich, University Hospital Zurich
- Christian Daniel Fankhauser
- Department of Urology, University of Zurich, University Hospital Zurich
- Cedric Poyet
- Department of Urology, University of Zurich, University Hospital Zurich
- Jelena Ljubicic
- Institute of Surgical Pathology, University Hospital Zurich
- Niels Rupp
- Institute of Surgical Pathology, University Hospital Zurich
- Jan H. Rüschoff
- Institute of Surgical Pathology, University Hospital Zurich
- Qing Zhong
- Institute of Surgical Pathology, University Hospital Zurich
- Andreas Beyer
- CECAD, University of Cologne
- Jiafu Ji
- Key laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute
- Ben C. Collins
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- Yansheng Liu
- Department of Pharmacology, Cancer Biology Institute, Yale University School of Medicine
- Gunnar Rätsch
- SIB Swiss Institute of Bioinformatics
- Peter J. Wild
- Institute of Surgical Pathology, University Hospital Zurich
- Ruedi Aebersold
- Department of Biology, Institute of Molecular Systems Biology, ETH Zurich
- DOI
- https://doi.org/10.1038/s41467-019-10513-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 8
Abstract
Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.
