Nature Communications (Sep 2018)

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

  • Alida Kindt,
  • Gerhard Liebisch,
  • Thomas Clavel,
  • Dirk Haller,
  • Gabriele Hörmannsperger,
  • Hongsup Yoon,
  • Daniela Kolmeder,
  • Alexander Sigruener,
  • Sabrina Krautbauer,
  • Claudine Seeliger,
  • Alexandra Ganzha,
  • Sabine Schweizer,
  • Rosalie Morisset,
  • Till Strowig,
  • Hannelore Daniel,
  • Dominic Helm,
  • Bernhard Küster,
  • Jan Krumsiek,
  • Josef Ecker

DOI
https://doi.org/10.1038/s41467-018-05767-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The role of the gut microbiota in hepatic lipid metabolism is controversial and incompletely understood. Here the authors perform multi-omics analyses of altered lipid metabolic processes in germ-free and specific pathogen-free mice, revealing how the gut microbiota affects hepatic fatty acid desaturation and elongation.