HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Lingling Xian; Dan Georgess; Tait Huso; Leslie Cope; Amy Belton; Yu-Ting Chang; Wenyong Kuang; Qihua Gu; Xiaoyan Zhang; Stefania Senger; Alessio Fasano; David L. Huso; Andrew J. Ewald; Linda M. S. Resar

doi:10.1038/ncomms15008

Nature Communications (Apr 2017)

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Lingling Xian,
Dan Georgess,
Tait Huso,
Leslie Cope,
Amy Belton,
Yu-Ting Chang,
Wenyong Kuang,
Qihua Gu,
Xiaoyan Zhang,
Stefania Senger,
Alessio Fasano,
David L. Huso,
Andrew J. Ewald,
Linda M. S. Resar

Affiliations

Lingling Xian: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Dan Georgess: Department of Cell Biology, The Johns Hopkins University School of Medicine
Tait Huso: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Leslie Cope: Division of Biostatistics, Department of Oncology, The Johns Hopkins University School of Medicine
Amy Belton: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Yu-Ting Chang: Department of Pathology, Pathobiology Graduate Program, The Johns Hopkins University School of Medicine
Wenyong Kuang: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Qihua Gu: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Xiaoyan Zhang: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine
Stefania Senger: Department of Pediatrics, Mucosal Immunology and Biology Research Center, Harvard Medical School, Massachusetts General Hospital East
Alessio Fasano: Department of Pediatrics, Mucosal Immunology and Biology Research Center, Harvard Medical School, Massachusetts General Hospital East
David L. Huso: Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine
Andrew J. Ewald: Department of Cell Biology, The Johns Hopkins University School of Medicine
Linda M. S. Resar: Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/ncomms15008
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell compartment and enrich the ISC niche.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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