Pharmaceuticals (Feb 2010)

Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain

  • Tiziana Borsello,
  • Xanthi Antoniou

DOI
https://doi.org/10.3390/ph3020379
Journal volume & issue
Vol. 3, no. 2
pp. 379 – 392

Abstract

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The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.

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