Haematologica (Feb 2008)

Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

  • Masamitsu Yanada,
  • Jin Takeuchi,
  • Isamu Sugiura,
  • Hideki Akiyama,
  • Noriko Usui,
  • Fumiharu Yagasaki,
  • Kazuhiro Nishii,
  • Yasunori Ueda,
  • Makoto Takeuchi,
  • Shuichi Miyawaki,
  • Atsuo Maruta,
  • Hiroto Narimatsu,
  • Yasushi Miyazaki,
  • Shigeki Ohtake,
  • Itsuro Jinnai,
  • Keitaro Matsuo,
  • Tomoki Naoe,
  • Ryuzo Ohno

DOI
https://doi.org/10.3324/haematol.11891
Journal volume & issue
Vol. 93, no. 2

Abstract

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To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 months). Twenty-eight out of 77 patients who had achieved CR relapsed. The probability of RFS was 50.5% at 2 years. Multivariate analysis revealed that the presence of secondary chromosome aberrations in addition to t(9;22) at diagnosis constitute an independent predictive value for RFS (p=0.027), and increase the risk of treatment failure by 2.8-fold.