Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals

Abstract

In recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including in chemico, in silico, and in vitro approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental Protection Agency (EPA)’s web-based CompTox Chemical Dashboard was developed and providing relevant data through a curation of diverse substances and predictive tools. In this review, we presented a comprehensive analysis of EPA CompTox Chemical dashboard’s available data, predictive tools and recent case studies using them. We also suggested a perspective of utility of EPA CompTox Chemical Dashboard for implementation of next generation risk assessment and toxicity prediction of environmental chemicals.

Keywords

• toxicity prediction
• next generation risk assessment
• new approach methodologies
• toxicology database
• epa comptox chemical dashboard