Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach

M. B. I. Lobbes; M. E. Kooi; E. Lutgens; A. W. Ruiters; V. Lima Passos; S. H. J. G. Braat; M. Rousch; H. Ten Cate; J. M. A. van Engelshoven; M. J. A. P. Daemen; S. Heeneman

doi:10.1155/2010/726207

International Journal of Vascular Medicine (Jan 2010)

Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach

M. B. I. Lobbes,
M. E. Kooi,
E. Lutgens,
A. W. Ruiters,
V. Lima Passos,
S. H. J. G. Braat,
M. Rousch,
H. Ten Cate,
J. M. A. van Engelshoven,
M. J. A. P. Daemen,
S. Heeneman

Affiliations

M. B. I. Lobbes: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
M. E. Kooi: Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
E. Lutgens: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
A. W. Ruiters: Department of Cardiology, Orbis Medical Center, P.O. Box 5500, 6130 MB Sittard, The Netherlands
V. Lima Passos: Department of Methodology and Statistics, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
S. H. J. G. Braat: Department of Cardiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
M. Rousch: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
H. Ten Cate: Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
J. M. A. van Engelshoven: Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
M. J. A. P. Daemen: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
S. Heeneman: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands

DOI: https://doi.org/10.1155/2010/726207
Journal volume & issue: Vol. 2010

Abstract

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We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.

Published in International Journal of Vascular Medicine

ISSN: 2090-2824 (Print); 2090-2832 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://onlinelibrary.wiley.com/journal/1839

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