Embryonal tumour with multi-layered rosettes a case based review of the literature

Abstract

The World Health organization updated the classification of central nervous system tumours in 2016 with more emphasis placed on molecular signature. This has led to widespread adaptation of more targeted therapy in neurosurgery.Primitive Neuroectodermal Tumour has been subdivided leading to the emergence of epidermal tumor with multi-layered rosettes as a separate entity.Neurosurgical centres in developing countries rely on assistance from more resource endowed institutions to make this diagnosis. Despite such collaborations, epidermal tumor with multi-layered rosettes remains a rare diagnosis with no universally accepted standard of treatment approach. The disease has a rapidly progressing character and portends a sinister prognosis despite multimodal therapy.

Keywords

• Embryonal tumor with multilayered rosettes (ETMR)
• C19MC amplification
• Surgery
• Prognosis
• Central nervous system neoplasms
• Cerebral primitive neuroectodermal tumor (PNET)