Retrovirology (Oct 2019)
BLV: lessons on vaccine development
- Alejandro Abdala,
- Irene Alvarez,
- Hélène Brossel,
- Luis Calvinho,
- Hugo Carignano,
- Lautaro Franco,
- Hélène Gazon,
- Christelle Gillissen,
- Malik Hamaidia,
- Clotilde Hoyos,
- Jean-Rock Jacques,
- Thomas Joris,
- Florent Laval,
- Marcos Petersen,
- Florent Porquet,
- Natalia Porta,
- Vanesa Ruiz,
- Roghaiyeh Safari,
- Guillermo Suárez Archilla,
- Karina Trono,
- Luc Willems
Affiliations
- Alejandro Abdala
- Estacion Experimental Agropecuaria Rafaela, INTA
- Irene Alvarez
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Hélène Brossel
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Luis Calvinho
- Estacion Experimental Agropecuaria Rafaela, INTA
- Hugo Carignano
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Lautaro Franco
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Hélène Gazon
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Christelle Gillissen
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Malik Hamaidia
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Clotilde Hoyos
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Jean-Rock Jacques
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Thomas Joris
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Florent Laval
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Marcos Petersen
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Florent Porquet
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Natalia Porta
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Vanesa Ruiz
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Roghaiyeh Safari
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- Guillermo Suárez Archilla
- Estacion Experimental Agropecuaria Rafaela, INTA
- Karina Trono
- Instituto de Virología e Innovaciones tecnológicas, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-CONICET
- Luc Willems
- Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liège (ULiège)
- DOI
- https://doi.org/10.1186/s12977-019-0488-8
- Journal volume & issue
-
Vol. 16,
no. 1
pp. 1 – 6
Abstract
Abstract Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
Keywords
