Platelet functions in healthy persons with genetic polymorphisms gpia(с807т), gpiiia(т1565с), gpipa(с434т), p2ry12(н1/н2), selp(-g1087a) platelet receptions

Abstract

Allele and genotype frequencies of 5 polymorphisms were studied in healthy population in Transbaikalian region. High percent of spontaneous and inductive aggregation were observed in subjects with three or more mutant allele (р < 0,05). These subjects developed maximum radius of aggregates only in spontaneous -1,7 ± 0,4 opt.un. (р < 0,05) and collagen-induced aggregation - 7,6 ± 2,5 opt.un. (р < 0,05).

Keywords

• platelets
• aggregate of platelet
• platelet receptions
• gene polymorphism
• population genetics