Nature Communications (Jun 2019)

A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies

  • Lotta Happonen,
  • Simon Hauri,
  • Gabriel Svensson Birkedal,
  • Christofer Karlsson,
  • Therese de Neergaard,
  • Hamed Khakzad,
  • Pontus Nordenfelt,
  • Mats Wikström,
  • Magdalena Wisniewska,
  • Lars Björck,
  • Lars Malmström,
  • Johan Malmström

DOI
https://doi.org/10.1038/s41467-019-10583-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma.