Molecular Autism (Apr 2020)

Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study

  • Toru Fujioka,
  • Kenji J. Tsuchiya,
  • Manabu Saito,
  • Yoshiyuki Hirano,
  • Muneaki Matsuo,
  • Mitsuru Kikuchi,
  • Yoshihiro Maegaki,
  • Damee Choi,
  • Sumi Kato,
  • Tokiko Yoshida,
  • Yuko Yoshimura,
  • Sawako Ooba,
  • Yoshifumi Mizuno,
  • Shinichiro Takiguchi,
  • Hideo Matsuzaki,
  • Akemi Tomoda,
  • Katsuyuki Shudo,
  • Masaru Ninomiya,
  • Taiichi Katayama,
  • Hirotaka Kosaka

DOI
https://doi.org/10.1186/s13229-020-00321-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Abstract Background Elucidating developmental changes in the symptoms of autism spectrum disorder (ASD) is important to support individuals with ASD. However, no report has clarified the developmental changes in attention to social information for a broad age range. The aim of this study was to investigate the developmental changes in attention to social information from early childhood to adolescence in individuals with ASD and typically developed (TD) children. Methods We recruited children with ASD (n = 83) and TD participants (n = 307) between 2 and 18 years of age. Using the all-in-one-eye-tracking system, Gazefinder, we measured the percentage fixation time allocated to areas of interest (AoIs) depicted in movies (the eyes and mouth in movies of a human face with/without mouth motion, upright and inverted biological motion in movies showing these stimuli simultaneously, people and geometry in preference paradigm movies showing these stimuli simultaneously, and objects with/without finger-pointing in a movie showing a woman pointing toward an object). We conducted a three-way analysis of variance, 2 (diagnosis: ASD and TD) by 2 (sex: male and female) by 3 (age group: 0–5, 6–11, and 12–18 years) and locally weighted the scatterplot smoothing (LOESS) regression curve on each AoI. Results In the face stimuli, the percentage fixation time to the eye region for the TD group increased with age, whereas the one for the ASD group did not. In the ASD group, the LOESS curves of the gaze ratios at the eye region increased up to approximately 10 years of age and thereafter tended to decrease. For the percentage fixation time to the people region in the preference paradigm, the ASD group gazed more briefly at people than did the TD group. Limitations It is possible that due to the cross-sectional design, the degree of severity and of social interest might have differed according to the subjects’ age. Conclusions There may be qualitative differences in abnormal eye contact in ASD between individuals in early childhood and those older than 10 years.

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