A temporary indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells

Tae Hyun Kim; Yang Wang; C. Ryan Oliver; Douglas H. Thamm; Laura Cooling; Costanza Paoletti; Kaylee J. Smith; Sunitha Nagrath; Daniel F. Hayes

doi:10.1038/s41467-019-09439-9

Nature Communications (Apr 2019)

A temporary indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells

Tae Hyun Kim,
Yang Wang,
C. Ryan Oliver,
Douglas H. Thamm,
Laura Cooling,
Costanza Paoletti,
Kaylee J. Smith,
Sunitha Nagrath,
Daniel F. Hayes

Affiliations

Tae Hyun Kim: Department of Chemical Engineering, University of Michigan
Yang Wang: Department of Chemical Engineering, University of Michigan
C. Ryan Oliver: Biomedical Engineering, University of Michigan
Douglas H. Thamm: Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University
Laura Cooling: Department of Pathology, University of Michigan
Costanza Paoletti: Department of Internal Medicine, University of Michigan Rogel Cancer Center
Kaylee J. Smith: Department of Chemical Engineering, University of Michigan
Sunitha Nagrath: Department of Chemical Engineering, University of Michigan
Daniel F. Hayes: Department of Internal Medicine, University of Michigan Rogel Cancer Center

DOI: https://doi.org/10.1038/s41467-019-09439-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

Read online

Ex vivo methods of circulating tumor cell (CTC) isolation use small blood volumes, limiting sensitivity and introducing analytical inaccuracies. The authors describe a proof-of-concept study of an in vivo aphaeresis system that continuously collects CTCs from a peripheral vein over several hours.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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