Nature Communications (Jun 2019)

ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

  • Javier Koh,
  • Yoko Itahana,
  • Ian H. Mendenhall,
  • Dolyce Low,
  • Eunice Xin Yi Soh,
  • Alvin Kunyao Guo,
  • Yok Teng Chionh,
  • Lin-Fa Wang,
  • Koji Itahana

DOI
https://doi.org/10.1038/s41467-019-10495-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the ABCB1 transporter.