Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Yuanyuan Li; Zhaochong Cai; Shunjie Liu; Haoke Zhang; Sherman T. H. Wong; Jacky W. Y. Lam; Ryan T. K. Kwok; Jun Qian; Ben Zhong Tang

doi:10.1038/s41467-020-15095-1

Nature Communications (Mar 2020)

Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Yuanyuan Li,
Zhaochong Cai,
Shunjie Liu,
Haoke Zhang,
Sherman T. H. Wong,
Jacky W. Y. Lam,
Ryan T. K. Kwok,
Jun Qian,
Ben Zhong Tang

Affiliations

Yuanyuan Li: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Zhaochong Cai: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, Zhejiang University
Shunjie Liu: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Haoke Zhang: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Sherman T. H. Wong: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Jacky W. Y. Lam: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Ryan T. K. Kwok: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology
Jun Qian: State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, Zhejiang University
Ben Zhong Tang: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Department of Chemical and Biological Engineering and Division of Life Science, The Hong Kong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-15095-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

Light has limited penetration depth in vivo which has led to increasing interest in NIR-II fluorophores. Here, the authors report on the design and testing of an organic aggregation induced emission fluorophore with high quantum yield and demonstrate imaging of vasculature and intestines in live mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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