Tight junction channel regulation by interclaudin interference

Nitesh Shashikanth; Marion M. France; Ruyue Xiao; Xenia Haest; Heather E. Rizzo; Jose Yeste; Johannes Reiner; Jerrold R. Turner

doi:10.1038/s41467-022-31587-8

Nature Communications (Jun 2022)

Tight junction channel regulation by interclaudin interference

Nitesh Shashikanth,
Marion M. France,
Ruyue Xiao,
Xenia Haest,
Heather E. Rizzo,
Jose Yeste,
Johannes Reiner,
Jerrold R. Turner

Affiliations

Nitesh Shashikanth: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Marion M. France: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Ruyue Xiao: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Xenia Haest: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Heather E. Rizzo: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Jose Yeste: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Johannes Reiner: Division of Gastroenterology and Endocrinology, Department of Medicine II, Rostock University Medical Center, Ernst-Heydemann-Str. 6
Jerrold R. Turner: Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-022-31587-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Tight junctions are formed by claudin proteins that can be classified as pore- or barrier-forming. Here, Shashikanth et al. report a third function, termed interclaudin interference, in which one claudin inhibits pore function of another claudin by disrupting its polymeric complexes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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