Nature Communications (Sep 2016)

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

  • Gijs van Ingen,
  • Jin Li,
  • André Goedegebure,
  • Rahul Pandey,
  • Yun Rose Li,
  • Michael E. March,
  • Vincent W. V. Jaddoe,
  • Marina Bakay,
  • Frank D. Mentch,
  • Kelly Thomas,
  • Zhi Wei,
  • Xiao Chang,
  • Heather S. Hain,
  • André G. Uitterlinden,
  • Henriette A. Moll,
  • Cornelia M. van Duijn,
  • Fernando Rivadeneira,
  • Hein Raat,
  • Robert J. Baatenburg de Jong,
  • Patrick M. Sleiman,
  • Marc P. van der Schroeff,
  • Hakon Hakonarson

DOI
https://doi.org/10.1038/ncomms12792
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

Read online

Acute otitis media (AOM) is an acute infection of middle ear mucosa and among the most common pediatric diseases. Here, the authors performed a genome-wide association study to link a variant in the FNDC1 locus on 6q25.3 and differential methylation status of the FNDC1gene with predisposition to AOM.