Gut Microbes (Dec 2024)

IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation

  • Wenjie Tang,
  • Yusen Wei,
  • Zhixiang Ni,
  • Kangwei Hou,
  • Xin M. Luo,
  • Haifeng Wang

DOI
https://doi.org/10.1080/19490976.2024.2323220
Journal volume & issue
Vol. 16, no. 1

Abstract

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ABSTRACTThe mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.

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