Frontiers in Aging Neuroscience (Sep 2022)
Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial
- Adrià Bermudo-Gallaguet,
- Adrià Bermudo-Gallaguet,
- Adrià Bermudo-Gallaguet,
- Mar Ariza,
- Mar Ariza,
- Rosalia Dacosta-Aguayo,
- Rosalia Dacosta-Aguayo,
- Daniela Agudelo,
- Neus Camins-Vila,
- Maria Boldó,
- Òscar Carrera,
- Sandra Vidal,
- Blai Ferrer-Uris,
- Albert Busquets,
- Marc Via,
- Marc Via,
- Marc Via,
- Guillem Pera,
- Guillem Pera,
- Cynthia Cáceres,
- Meritxell Gomis,
- Alberto García-Molina,
- José María Tormos,
- Ana Arrabé,
- Gustavo Diez,
- Maria José Durà Mata,
- Pere Torán-Monserrat,
- Pere Torán-Monserrat,
- Juan José Soriano-Raya,
- Juan José Soriano-Raya,
- Sira Domènech,
- Alexandre Perera-Lluna,
- Alexandre Perera-Lluna,
- Kirk I. Erickson,
- Kirk I. Erickson,
- Maria Mataró,
- Maria Mataró,
- Maria Mataró
Affiliations
- Adrià Bermudo-Gallaguet
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Adrià Bermudo-Gallaguet
- Institut de Neurociències, University of Barcelona, Barcelona, Spain
- Adrià Bermudo-Gallaguet
- Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
- Mar Ariza
- Institut de Neurociències, University of Barcelona, Barcelona, Spain
- Mar Ariza
- Department of Medicine, University of Barcelona, Barcelona, Spain
- Rosalia Dacosta-Aguayo
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Rosalia Dacosta-Aguayo
- Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
- Daniela Agudelo
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Neus Camins-Vila
- Institut Nacional d’Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
- Maria Boldó
- Department of Physical Medicine and Rehabilitation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Òscar Carrera
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Sandra Vidal
- Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Blai Ferrer-Uris
- Institut Nacional d’Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
- Albert Busquets
- Institut Nacional d’Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
- Marc Via
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Marc Via
- Institut de Neurociències, University of Barcelona, Barcelona, Spain
- Marc Via
- Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
- Guillem Pera
- Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
- Guillem Pera
- Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Cynthia Cáceres
- Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Meritxell Gomis
- Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Alberto García-Molina
- 0Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
- José María Tormos
- 0Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
- Ana Arrabé
- 1Nirakara Lab, Mindfulness and Cognitive Science Extraordinary Chair, Universidad Complutense de Madrid, Madrid, Spain
- Gustavo Diez
- 1Nirakara Lab, Mindfulness and Cognitive Science Extraordinary Chair, Universidad Complutense de Madrid, Madrid, Spain
- Maria José Durà Mata
- Department of Physical Medicine and Rehabilitation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Pere Torán-Monserrat
- Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
- Pere Torán-Monserrat
- Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Juan José Soriano-Raya
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Juan José Soriano-Raya
- Institut de Neurociències, University of Barcelona, Barcelona, Spain
- Sira Domènech
- 2Institut de Diagnòstic per la Imatge, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
- Alexandre Perera-Lluna
- Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
- Alexandre Perera-Lluna
- 3B2SLab, Departament d’Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
- Kirk I. Erickson
- 4Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
- Kirk I. Erickson
- 5PROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain
- Maria Mataró
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
- Maria Mataró
- Institut de Neurociències, University of Barcelona, Barcelona, Spain
- Maria Mataró
- Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
- DOI
- https://doi.org/10.3389/fnagi.2022.936077
- Journal volume & issue
-
Vol. 14
Abstract
BackgroundPost-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health.Materials and methodsOne hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans.ResultsThe effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample.DiscussionThe MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients’ cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes.Clinical trial registrationwww.ClinicalTrials.gov, identifier NCT04759950.
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