Regulation of nuclear mTORC1

Abstract

mTORC1 integrates diverse upstream signals to control cell growth and metabolism. We previously showed that mTORC1 activity is spatially compartmentalized to ensure its signaling specificity. In a recently published study, we demonstrated the existence of mTORC1 activity in the nucleus and identified a unique mode of its regulation in the nuclear compartment.

Keywords

• raptor
• spatial compartmentalization
• protein kinase
• nuclear translocation
• signaling specificity