Nature Communications (Mar 2021)
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
- Gabriele G. Schiattarella,
- Francisco Altamirano,
- Soo Young Kim,
- Dan Tong,
- Anwarul Ferdous,
- Hande Piristine,
- Subhajit Dasgupta,
- Xuliang Wang,
- Kristin M. French,
- Elisa Villalobos,
- Stephen B. Spurgin,
- Maayan Waldman,
- Nan Jiang,
- Herman I. May,
- Theodore M. Hill,
- Yuxuan Luo,
- Heesoo Yoo,
- Vlad G. Zaha,
- Sergio Lavandero,
- Thomas G. Gillette,
- Joseph A. Hill
Affiliations
- Gabriele G. Schiattarella
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Francisco Altamirano
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Soo Young Kim
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Dan Tong
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Anwarul Ferdous
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Hande Piristine
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Subhajit Dasgupta
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Xuliang Wang
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Kristin M. French
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Elisa Villalobos
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Stephen B. Spurgin
- Department of Pediatrics, University of Texas Southwestern Medical Center
- Maayan Waldman
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Nan Jiang
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Herman I. May
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Theodore M. Hill
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Yuxuan Luo
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Heesoo Yoo
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Vlad G. Zaha
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Sergio Lavandero
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Thomas G. Gillette
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- Joseph A. Hill
- Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-21931-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.
