Nature Communications (Oct 2022)

Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling

  • Masaji Sakaguchi,
  • Shota Okagawa,
  • Yuma Okubo,
  • Yuri Otsuka,
  • Kazuki Fukuda,
  • Motoyuki Igata,
  • Tatsuya Kondo,
  • Yoshifumi Sato,
  • Tatsuya Yoshizawa,
  • Takaichi Fukuda,
  • Kazuya Yamagata,
  • Weikang Cai,
  • Yu-Hua Tseng,
  • Nobuo Sakaguchi,
  • C. Ronald Kahn,
  • Eiichi Araki

DOI
https://doi.org/10.1038/s41467-022-33842-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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The insulin signalling cascade can be inhibited by phosphatases, including Ser/Thr protein phosphatase 2A (PP2A). Here the authors show that Alpha4, a regulator of the PP2A catalytic subunit, modulates insulin receptor tyrosine phosphorylation via the YBX-1/PTP1B pathway and is involved in maintenance of adipose tissue homeostasis and systemic metabolism.