OncoTargets and Therapy (Mar 2021)
Bronchiolar Adenoma Transforming to Invasive Mucinous Adenocarcinoma: A Case Report
Abstract
Xu Han,1,* Jialin Hao,2,* Suling Ding,3 En-Hua Wang,1 Liang Wang1 1Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, People’s Republic of China; 2Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, People’s Republic of China; 3Department of Pathology, Jinzhou Central Hospital, Jinzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liang WangDepartment of Pathology, First Affiliated Hospital and College and Basic Medical Sciences, China Medical University, Shenyang, People’s Republic of ChinaTel/Fax +86 24 23261638Email [email protected]: Bronchiolar adenoma (BA) is recognized as a neoplasm with benign clinical course. Histologically, BA is characterized by nodular proliferation of the bilayered bronchiolar-type epithelium, including multipartite epithelial cells and a continuous layer of basal cells. Recent reports have revealed the frequent presence of driver gene mutations in BA, suggesting its neoplastic nature. However, it is still debatable whether BA has malignant potential. Herein, we report the first case of BA harboring the same KRAS mutation with the adjacent invasive mucinous adenocarcinoma (IMA). Additionally, the loss of continuity of the basal cell layer in the junctional zone between BA and IMA indicated a malignant transformation from BA to IMA in this particular case.Keywords: bronchiolar adenoma, invasive mucinous adenocarcinoma, KRAS, transformation
