Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

Chenxu Ge; Jun Tan; Xianling Dai; Qin Kuang; Shaoyu Zhong; Lili Lai; Chao Yi; Yan Sun; Jing Luo; Chufeng Zhang; Liancai Zhu; Bochu Wang; Minxuan Xu

doi:10.1038/s41467-022-33493-5

Nature Communications (Oct 2022)

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

Chenxu Ge,
Jun Tan,
Xianling Dai,
Qin Kuang,
Shaoyu Zhong,
Lili Lai,
Chao Yi,
Yan Sun,
Jing Luo,
Chufeng Zhang,
Liancai Zhu,
Bochu Wang,
Minxuan Xu

Affiliations

Chenxu Ge: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Jun Tan: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Xianling Dai: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Qin Kuang: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Shaoyu Zhong: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Lili Lai: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Chao Yi: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Yan Sun: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education
Jing Luo: College of Modern Health Industry, Chongqing University of Education
Chufeng Zhang: Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences
Liancai Zhu: Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University
Bochu Wang: Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University
Minxuan Xu: Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education

DOI: https://doi.org/10.1038/s41467-022-33493-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Mechanisms underlying the pathogenesis of nonalcoholic steatohepatitis are unclear. Here, the authors show that ROS-mediated DUSP22 degradation participates in the progression of fatty liver, contributing to the development of NASH and associated HCC via regulating FAK and its downstream ERK1/2 and NF-κB signaling cascade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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