AIM: To analyze the clinical efficacy and postoperative impacts of coaxial micro-incision phacoemulsification on patients with cataract, and explore the application value of the surgical method. METHODS: Totally 300 patients(300 eyes)who received the coaxial micro-incision phacoemulsification were randomly divided into the observation group(150 case)and the control group(150 case). Patients in the observation group and control group were treated by coaxial micro-incision phacoemulsification and traditional coaxial phacoemulsification, respectively. The effective phaco time(EPT), average ultrasound energy(AVE), intraoperative anterior chamber stability and postoperative recovery time were compared between the two groups, as well as the uncorrected visual acuity(UCVA), the surgically induced astigmatism(SIA)and the loss rate of corneal endothelial cells at 1d, 1wk, 1 and 3mo after surgery. RESULTS: No significant difference of EPT, AVE and the rate of patients with stable anterior chamber were found between the two groups(P>0.05), as well as the UCVA, SIA and the corneal endothelial cells in patients before surgery(P>0.05).The postoperative recovery time of patients in the observation group was obviously shorter than that in the control group(PPPPPCONCLUSION: The coaxial micro-incision phacoemulsification had a high clinical value as it possesses the advantages of more rapid UCVA recovery, less influence on SIA and less loss of corneal endothelial cell.