From Schönlein-Henoch purpura to IgA-vasculitis: pathogenetic aspects of the disease

Abstract

Investigation’s history and nomenclature’s evolution of the IgA-vasculitis are presented in the article. Pathogenesis of the renal and skin damages is discussed in details, particularly abnormalities of the IgA-immunity and systemic endotoxemia. Relevant world’s literature is cited.

Keywords

• systemic vasculitides
• schönlein-henoch purpura
• hemorrhagic vasculitis
• iga-vasculitis
• iga-nephropathy
• defective iga glycosylation
• shwartzman reaction
• endotoxemia