Nature Communications (Jun 2021)
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
- Maria De Risi,
- Michele Tufano,
- Filomena Grazia Alvino,
- Maria Grazia Ferraro,
- Giulia Torromino,
- Ylenia Gigante,
- Jlenia Monfregola,
- Elena Marrocco,
- Salvatore Pulcrano,
- Lea Tunisi,
- Claudia Lubrano,
- Dulce Papy-Garcia,
- Yaakov Tuchman,
- Alberto Salleo,
- Francesca Santoro,
- Gian Carlo Bellenchi,
- Luigia Cristino,
- Andrea Ballabio,
- Alessandro Fraldi,
- Elvira De Leonibus
Affiliations
- Maria De Risi
- Telethon Institute of Genetics and Medicine
- Michele Tufano
- Telethon Institute of Genetics and Medicine
- Filomena Grazia Alvino
- Telethon Institute of Genetics and Medicine
- Maria Grazia Ferraro
- Telethon Institute of Genetics and Medicine
- Giulia Torromino
- Telethon Institute of Genetics and Medicine
- Ylenia Gigante
- Telethon Institute of Genetics and Medicine
- Jlenia Monfregola
- Telethon Institute of Genetics and Medicine
- Elena Marrocco
- Telethon Institute of Genetics and Medicine
- Salvatore Pulcrano
- Institute of Genetics and Biophysics, CNR
- Lea Tunisi
- Institute of Biomolecular Chemistry, CNR
- Claudia Lubrano
- Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia
- Dulce Papy-Garcia
- Université Paris-Est Créteil Val de Marne (UPEC)
- Yaakov Tuchman
- Department of Materials Science and Engineering, Stanford University
- Alberto Salleo
- Department of Materials Science and Engineering, Stanford University
- Francesca Santoro
- Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia
- Gian Carlo Bellenchi
- Institute of Genetics and Biophysics, CNR
- Luigia Cristino
- Institute of Biomolecular Chemistry, CNR
- Andrea Ballabio
- Telethon Institute of Genetics and Medicine
- Alessandro Fraldi
- Telethon Institute of Genetics and Medicine
- Elvira De Leonibus
- Telethon Institute of Genetics and Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23903-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.
